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	Provedor de dados BJMBR (1) Autor Guo,Dongmei (1) Liu,Han (1) Zhao,Zhengbo (1) Palavra-chave Aliskiren (1) Apoptosis (1) Cardiac hypertrophy (1) Fibrosis (1) Mammalian target of rapamycin (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2020 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Aliskiren attenuates cardiac dysfunction by modulation of the mTOR and apoptosis pathways BJMBR Zhao,Zhengbo; Liu,Han; Guo,Dongmei. Aliskiren (ALS) is well known for its antihypertensive properties. However, the potential underlying the molecular mechanism and the anti-hypertrophic effect of ALS have not yet been fully elucidated. The aim of the present study was to investigate the role of ALS in mammalian target of rapamycin (mTOR) and apoptosis signaling using in vivo and in vitro models of cardiac hypertrophy. A rat model of cardiac hypertrophy was induced by isoproterenol treatment (5 mg·kg-1·day-1) for 4 weeks, with or without ALS treatment at 20 mg·kg-1·day-1. The expression of hypertrophic, fibrotic, and apoptotic markers was determined by RT-qPCR. The protein expression of apoptotic markers mTOR and p-mTOR was assessed by western blot analysis. The proliferation of H9C2 cells... Tipo: Info:eu-repo/semantics/article Palavras-chave: Aliskiren; Cardiac hypertrophy; Fibrosis; Mammalian target of rapamycin; Apoptosis. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000200602 Registros recuperados: 1 Primeira ... 1 ... Última

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